After several years on Wordpress, Lot 49 Labs has moved to Squarespace. So far, I'm impressed. For all the freedom afforded by Wordpress, it was a frequent hassle in terms of maintenance and updates. And certain templates perform poorly if you don't take steps to optimize them.
Squarespace is easier to use and the commerce integration is quite well done. Its templates also look quite good. I'm looking forward to spending less time managing websites.